It is the near-future where advances in biotechnology have made it possible to create synthetic body parts and even brains that behave just like human tissue. But it is still a controversial and very illegal practice. Jenna Fox has just woken up after a year in a coma, and the world she wakes up to is completely unfamiliar to her. Slowly a few memories begin to return, and not only her own memories, but she can recite Thoreau and the details of obscure events in history as though she pulled them out of a textbook, and she can even remember things that happened when she was only a year old. But she can't seem to remember the car accident or what happened to her friends Kara and Locke who were in the car. As her memories begin to return, Jenna begins to make some very disturbing discoveries about her existence, and even her own humanity. Is she real, or is she something else?